Mozzarella Pesto Chicken Grilled Cheese

Featured in: Warm Weekend Brunch Plates

Discover this mouthwatering grilled cheese combining shredded chicken breast, creamy mozzarella, and vibrant basil pesto on toasted bread. Simple to prepare in just 20 minutes, this American-Italian fusion sandwich delivers satisfying flavors with minimal effort. Spread softened butter on bread, layer pesto, chicken, and cheese, then cook in a skillet until golden brown and melted. Perfect as a main dish for two, with optional additions like fresh tomato slices and Parmesan for extra richness.

Updated on Tue, 20 Jan 2026 13:07:00 GMT
Golden-brown grilled cheese sandwich with shredded chicken, melted mozzarella, and vibrant basil pesto on sourdough. Save
Golden-brown grilled cheese sandwich with shredded chicken, melted mozzarella, and vibrant basil pesto on sourdough. | wheatkettle.com

The first time I made this pesto chicken grilled cheese, I was snowed in during a March storm and working with whatever I had in the fridge. The combination ended up being so good that my roommate actually asked if I could make it again the next day. There's something about the way the salty mozzarella melts into that herby pesto that feels like it was always meant to be. Now whenever I smell basil and butter together, I'm right back in that tiny kitchen watching snow pile up outside the window.

Last summer, I made these for my sister after she spent a long day moving into her new apartment. She took one bite, stopped mid conversation, and just said oh wow. We ended up sitting crosslegged on her living room floor among unpacked boxes, eating them straight from the cutting board and agreeing that grilled cheese had never tasted this grown up.

Ingredients

  • Bread choice: Sourdough gives you that perfect tangy crunch and structural integrity to hold everything together without getting soggy
  • Fresh mozzarella: The key is slicing it thin enough to melt evenly but thick enough that you get those gorgeous cheese pulls with every bite
  • Unsalted butter: Softening it first means you can spread it evenly without tearing the bread, which I learned the hard way after too many patchwork jobs
  • Shredded chicken breast: Rotisserie chicken from the grocery store is absolutely fine here, and honestly saves so much time on weeknights
  • Basil pesto: Homemade is lovely but storebought works perfectly, just look for one with good color and not too much oil pooling on top

Instructions

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Layer the foundation:
Lay out all four bread slices and spread about a tablespoon and a half of pesto onto two of them, going almost to the edges so every bite gets that basil flavor.
Build the sandwiches:
Divide the shredded chicken evenly between the two pesto covered slices, then arrange the mozzarella on top of the chicken. Add tomato slices or fresh basil now if you're using them, and finish with a little Parmesan for that extra salty punch.
Butter the outside:
Place the remaining bread slices on top to close the sandwiches, then spread softened butter generously on the exterior of both sides. This is what creates that golden, restaurant style crust.
Grill to perfection:
Heat your skillet over medium heat and place the sandwiches inside, pressing down gently with your spatula. Cook for about 3 or 4 minutes on the first side until deeply golden, then carefully flip and cook another 3 to 4 minutes until the cheese is melting and the bread is crisp all over.
Rest and serve:
Let the sandwiches rest for a full minute on a cutting board so the cheese sets slightly, then slice diagonally and serve while still hot and gooey.
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Stir sauces, sauté vegetables, and serve meals gently while adding a charming touch to everyday cooking.
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Toasted Mozzarella Pesto Chicken Grilled Cheese cut diagonally, revealing juicy chicken and gooey cheese layers. Save
Toasted Mozzarella Pesto Chicken Grilled Cheese cut diagonally, revealing juicy chicken and gooey cheese layers. | wheatkettle.com

My dad always says that the real test of a grilled cheese is whether it needs soup on the side. These sandwiches definitely don't. They're hearty and complete enough to stand alone, though I won't tell anyone if you want to dunk them in tomato soup anyway.

Choosing Your Bread

I've tried this with everything from basic white bread to ciabatta, and sourdough really does win. Its tangy flavor cuts through the rich cheese and pesto, plus it develops this incredible crunch that holds up beautifully against the moist filling. Ciabatta works too if you want something chewier, just watch it closely since it can go from golden to dark quickly.

Make Ahead Strategy

You can assemble the sandwiches completely up to an hour before cooking, just wrap them tightly in plastic wrap and keep them at room temperature. Don't refrigerate assembled sandwiches or the bread will get soggy. When you're ready to cook, just unwrap and proceed with the buttering step.

Serving Suggestions

A crisp white wine like pinot grigio cuts through the richness perfectly, but sparkling water with a squeeze of lemon is just as refreshing. If you want something on the side, a simple arugula salad dressed with olive oil and lemon adds nice freshness without competing with the sandwich itself.

  • Let the skillet come to temperature fully before adding the first sandwich for even browning
  • If cheese starts to escape, don't panic, just tuck it back in with your spatula while it's still melty
  • A knife warmed under hot water slices through the melted cheese without dragging
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Freshly made Mozzarella Pesto Chicken Grilled Cheese served hot, with melted mozzarella and basil pesto. Save
Freshly made Mozzarella Pesto Chicken Grilled Cheese served hot, with melted mozzarella and basil pesto. | wheatkettle.com

There's something so deeply satisfying about biting into a grilled cheese that's been elevated with just a few thoughtful touches. This is the kind of meal that turns a random Tuesday into something worth remembering.

Common Recipe Questions

Can I use store-bought rotisserie chicken?

Yes, rotisserie chicken works perfectly for convenience. Simply shred the meat and use as directed. This saves preparation time while maintaining delicious flavor.

What bread works best for this sandwich?

Sourdough and Italian bread are recommended, but you can also try ciabatta or multigrain for different textures. Choose bread sturdy enough to hold the melted cheese without falling apart.

How do I make this sandwich vegetarian?

Replace the chicken with grilled vegetables such as zucchini or roasted peppers. The pesto and mozzarella provide plenty of flavor and satisfying richness on their own.

What temperature should the skillet be?

Heat your skillet or grill pan over medium heat. This ensures the bread toasts to golden brown while giving the cheese time to melt completely without burning.

Can I make homemade pesto?

Absolutely. Homemade pesto tastes excellent in this sandwich. Blend fresh basil, garlic, pine nuts, Parmesan, and olive oil for a vibrant sauce that elevates the entire dish.

What pairs well with this sandwich?

Serve alongside crisp Italian white wine, sparkling water with lemon, or a light salad. These beverages and sides complement the rich, savory flavors beautifully.

Mozzarella Pesto Chicken Grilled Cheese

Golden grilled cheese with shredded chicken, fresh pesto, and melted mozzarella. A savory fusion sandwich perfect for lunch or dinner.

Prep Duration
10 minutes
Cook Duration
10 minutes
Overall Time
20 minutes
Created by Lillian Roberts


Skill Level Easy

Cuisine Type American Italian Fusion

Makes 2 Portions

Diet Info None specified

What You Need

Bread & Dairy

01 4 slices sourdough or Italian bread
02 4 oz fresh mozzarella, sliced or shredded
03 2 tbsp unsalted butter, softened

Protein

01 1 cup cooked, shredded chicken breast

Sauces & Spreads

01 3 tbsp basil pesto, store-bought or homemade

Optional Add-Ins

01 2 tbsp grated Parmesan cheese
02 1 small tomato, thinly sliced
03 Fresh basil leaves

Steps

Step 01

Prepare Bread: Lay out the bread slices and spread 1 to 1.5 tbsp pesto onto two of the slices.

Step 02

Layer Chicken: Evenly distribute the shredded chicken on top of the pesto-covered slices.

Step 03

Add Cheese and Toppings: Layer mozzarella cheese over the chicken. Add tomato slices and fresh basil if using. Sprinkle with Parmesan for extra flavor, if desired.

Step 04

Form Sandwiches: Top with the remaining bread slices to form complete sandwiches.

Step 05

Butter Exterior: Spread the softened butter on the outsides of each sandwich, covering both top and bottom surfaces.

Step 06

Cook Sandwiches: Heat a large skillet or grill pan over medium heat. Place the sandwiches in the skillet, pressing them slightly with a spatula. Cook for 3 to 4 minutes per side, or until the bread is golden brown and the cheese is melted.

Step 07

Rest and Serve: Remove from the skillet, let rest for 1 minute, then cut in half and serve warm.

Essential Gear

  • Skillet or grill pan
  • Spatula
  • Knife
  • Cutting board

Allergy Notice

Read each ingredient label for allergens and talk to a professional if you're unsure.
  • Contains dairy: mozzarella, butter, Parmesan
  • Contains wheat and gluten in bread
  • Contains tree nuts if pesto contains pine nuts
  • Check store-bought pesto for nut and cheese allergens

Nutrition Details (per serving)

Details here are for general info and aren't meant as medical advice.
  • Kcal: 520
  • Fats: 27 grams
  • Carbohydrates: 32 grams
  • Proteins: 36 grams